Harper’s Illustrated Biochemistry (32nd Ed.) By Peter J. Kennelly, Kathleen M. Botham

Free download Harper’s Illustrated Biochemistry (32nd edition) authored by Peter J. Kennelly, Kathleen M. Botham, Owen P. McGuinness, Victor W. Rodwell and P. Anthony Weil in pdf.

As always, Harper’s Illustrated Biochemistry continues to emphasize the close relationship of biochemistry to the understanding of diseases, their pathology, and the practice of medicine. With the retirement of long-time contributor David A. Bender, Prof. Owen P. McGuinness of Vanderbilt University has joined as a new coauthor. In addition to the fresh perspectives and novel insights provided by Prof. McGuinness, the contents of most chapters have been updated and provide the reader with the most current and pertinent information.

All 58 chapters of the thirty-second edition place major emphasis on the medical relevance of biochemistry. Topics are organized under 11 major headings. In order to assist study and to facilitate retention of the contained information, Questions follow each Section. An Answer Bank follows Chapter 58.

Contents

Section I: Structures & Functions of Proteins & Enzymes

• Biochemistry & Medicine
• Water & pH
• Amino Acids & Peptides
• Proteins: Determination of Primary Structure
• Proteins: Higher Orders of Structure

Section II: Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals

• Proteins: Myoglobin & Hemoglobin
• Enzymes: Mechanism of Action
• Enzymes: Kinetics
• Enzymes: Regulation of Activities
• The Biochemical Roles of Transition Metals

Section III: Bioenergetics

• Bioenergetics: The Role of ATP
• Biologic Oxidation
• The Respiratory Chain & Oxidative Phosphorylation

Section IV: Metabolism of Carbohydrates

• Overview of Metabolism & the Provision of Metabolic Fuels
• Saccharides (ie, Carbohydrates) of Physiological Significance
• The Citric Acid Cycle: A Pathway Central to Carbohydrate, Lipid, & Amino Acid Metabolis
• Glycolysis & the Oxidation of Pyruvate
• Metabolism of Glycogen
• Gluconeogenesis & the Control of Blood Glucose
• The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism

Section V: Metabolism of Lipids

• Lipids of Physiologic Significance
• Oxidation of Fatty Acids: Ketogenesis
• Biosynthesis of Fatty Acids & Eicosanoids
• Metabolism of Acylglycerols & Sphingolipids
• Lipid Transport & Storage
• Cholesterol Synthesis, Transport, & Excretion

Section VI: Metabolism of Proteins & Amino Acids

• Biosynthesis of the Nutritionally Nonessential Amino Acids
• Catabolism of Proteins & of Amino Acid Nitrogen
• Catabolism of the Carbon Skeletons of Amino Acids
• Conversion of Amino Acids to Specialized Products
• Porphyrins & Bile Pigments

Section VII: Structure, Function, & Replication of Informational Macromolecules

• Nucleotides
• Metabolism of Purine & Pyrimidine Nucleotides
• Nucleic Acid Structure & Function
• DNA Organization, Replication, & Repair
• RNA Synthesis, Processing, & Modification
• Protein Synthesis & the Genetic Code
• Regulation of Gene Expression
• Molecular Genetics, Recombinant DNA, & Genomic Technology

Section VIII: Biochemistry of Extracellular & Intracellular Communication

• Membranes: Structure & Function
• The Diversity of the Endocrine System
• Hormone Action & Signal Transduction

Section IX: Special Topics (A)

• Nutrition, Digestion, & Absorption
• Micronutrients: Vitamins & Minerals
• Free Radicals & Antioxidant Nutrients
• Glycoproteins
• Metabolism of Xenobiotics
• Clinical Biochemistry

Section X: Special Topics (B)

• Intracellular Traffic & Sorting of Proteins
• The Extracellular Matrix
• Muscle & the Cytoskeleton
• Plasma Proteins & Immunoglobulins
• Red Blood Cells
• White Blood Cells

Section XI: Special Topics (C)

• Hemostasis & Thrombosis
• Cancer: An Overview
• The Biochemistry of Aging
• Biochemical Case Histories

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