Free download Biochemistry (4th edition) authored by Christopher K. Mathews, K. E. Van Holde, Dean R. Appling and Spencer J. Anthony-Cahill in pdf.
In addition to dealing with the vast amount of new information appearing since the publication of the third edition in 2000, this new edition introduces three significant changes. First is more emphasis upon biochemical reaction mechanisms in the enzymes and metabolism chapters. Second is a significant reorganization in the chapters dealing with intermediary metabolism.
The coverage of carbohydrate metabolism has been unified, so that we now present glycolysis, gluconeogenesis, glycogen metabolism, and the pentose phosphate pathway in one chapter (Chapter 13). To accomplish this without excessive expansion of the chapter, we moved the section on complex carbohydrate metabolism to Chapter 9; instructors can present this material as part of the metabolism section of the course, if they prefer.
Redox thermodynamics has been moved from Chapter 15 (Biological Oxidations) to Chapter 3 (Bioenergetics), where it more properly belongs. The material on interorgan coordination in mammalian metabolism has been split into two chapters—Chapter 18 (Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates) and Chapter 23 (Signal Transduction).
The third major change is the reorganization of genetic biochemistry in the last major section of the book. As in previous editions, we introduce processes in biological information transfer early, in Chapter 4, with details presented later. In addition, we have integrated prokaryotic and eukaryotic informational metabolism, rather than presenting them in separate chapters, as in previous editions.
The four genetic biochemistry chapters in previous editions are now six—Chapters 24 (Genome Organization), 25 (DNA Replication), 26 (Information Restructuring), 27 (Transcription and Its Control), 28 (Protein Synthesis and Processing), and 29 (Control of Gene Expression).
Part 1: The Realm of Biochemistry
- The Scope of Biochemistry
- The Matrix of Life: Weak Interactions in an Aqueous Environment
- The Energetics of Life
Part 2: Molecular Architecture of Living Matter
- Nucleic Acids
- Introduction to Proteins: The Primary Level of Protein Structure
- The Three-Dimensional Structure of Proteins
- Protein Function and Evolution
- Contractile Proteins and Molecular Motors
- Carbohydrates: Sugars, Saccharides, Glycans
- Lipids, Membranes, and Cellular Transport
Part 3: Dynamics of Life: Catalysis and Control of Biochemical Reactions
- Enzymes: Biological Catalysts
- Chemical Logic of Metabolism
Part 4: Dynamics of Life: Energy, Biosynthesis, and Utilization of Precursors
- Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway
- Citric Acid Cycle and Glyoxylate Cycle
- Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism
- Lipid Metabolism I: Fatty Acids, Triacylglycerols, and Lipoproteins
- Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates
- Lipid Metabolism II: Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids
- Metabolism of Nitrogenous Compounds I: Principles of Biosynthesis, Utilization, and Turnover
- Metabolism of Nitrogenous Compounds II: Amino Acids, Porphyrins, and
- Nucleotide Metabolism
- Mechanisms of Signal Transduction
Part 5: Information
- Genes, Genomes, and Chromosomes
- DNA Replication
- DNA Restructuring: Repair, Recombination, Rearrangement, Amplification
- Information Readout: Transcription and Post-transcriptional Processing
- Information Decoding: Translation and Post-translational Protein Processing
- Regulation of Gene Expression
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