Free download Biochemistry – An Organic Chemistry Approach written by Michael B. Smith in pdf.
According to the author, “The focus of this book is to use organic chemistry principles and reactions to explain the fundamentals of biochemistry. The inspiration for this book came from teaching the second semester of organic chemistry with many students who were taking introductory biochemistry at the same time.
Many students commented that the things we were discussing in organic chemistry helped explain and better understand the concepts they were discussing or had discussed in biochemistry. On many occasions, topics were discussed in organic chemistry that had been covered previously in the biochemistry course.
An understanding of the organic chemistry reactions and mechanisms helped the students better understand many of those biochemical principles. It is hoped that understanding the organic chemistry foundations of biochemistry will provide similar assistance to students today.
Where feasible, organic chemical reactions such as those found in a typical undergraduate organic chemistry course are included in this book to bring their biological chemistry counterparts into perspective.
The first chapter is meant as a review of the fundamentals of an undergraduate organic chemistry course. For those who have not had a full organic chemistry course, this chapter will not suffice. This chapter is only intended as a supplement for an organic chemistry course and to function as a review for the biochemical principles to follow.
The next chapter discusses the importance of water in chemistry and also acid-base chemistry Elimination reactions such as E2 and E1 reactions are introduced here as well. The third chapter discusses nucleophilic substitution and chapter Chapter 4 discusses radicals and radical reactions. Dienes and conjugated systems are discussed in Chapter 5, along with sigmatropic rearrangements.
Enols and enolate reactions are discussed in the next chapter, including aldol-type reactions and Claisen condensation type reactions.”
- Fundamental Principles of Organic Chemistry
- The Importance of Water in Biochemical Systems
- Nucleophiles and Electrophiles
- Dienes and Conjugated Carbonyl Compounds in Biochemistry
- Enolates and Enolate Anions
- Aromatic Compounds and Heterocyclic Compounds
- Carbon–Metal Bonds, Chelating Agents and Coordination Complexes
- Amino Acids
- Peptides and Proteins
- Nucleic Acids, Nucleosides and Nucleotides
- Answers to Homework Problems
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