Molecular Biology of the Cell (6th Ed.) By Alberts, Johnson, Lewis, Morgan, Raff, Roberts and Walter

Free download Molecular Biology of the Cell (6th edition) written by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter in pdf.

In preparing this new edition, we have inevitably had to make some difficult decisions. In order to incorporate exciting new discoveries, while at the same time keeping the book portable, much has had to be excised. We have added new sections, such as those on new RNA functions, advances in stem cell biology, new methods for studying proteins and genes and for imaging cells, advances in the genetics and treatment of cancer, and timing, growth control, and morphogenesis in development.

The chemistry of cells is extremely complex, and any list of cell parts and their interactions—no matter how complete—will leave huge gaps in our understanding. We now realize that to produce convincing explanations of cell behavior will require quantitative information about cells that is coupled to sophisticated mathematical/ computational approaches—some not yet invented. As a consequence, an emerging goal for cell biologists is to shift their studies more toward quantitative description and mathematical deduction. We highlight this approach and some of its methods in a new section at the end of Chapter 8.

Although the chapters of this book can be read independently of one another, they are arranged in a logical sequence of five parts. The first three chapters of Part I cover elementary principles and basic biochemistry. They can serve either as an introduction for those who have not studied biochemistry or as a refresher course for those who have. Part II deals with the storage, expression, and transmission of genetic information.

A selection of problems, written by John Wilson and Tim Hunt, appears in the text at the end of each chapter. New to this edition are problems for the last four chapters on multicellular organisms.

Contents

PART I: Introduction to the Cell

• Cells and Genomes
• Cell Chemistry and Bioenergetics
• Proteins

PART II: Basic Genetic Mechanisms

• DNA, Chromosomes, and Genomes
• DNA Replication, Repair, and Recombination
• How Cells Read the Genome: From DNA to Protein
• Control of Gene Expression

PART III: Ways of Working with Cells

• Analyzing Cells, Molecules, and Systems
• Visualizing Cells

PART IV: Internal Organization of the Cell

• Membrane Structure
• Membrane Transport of Small Molecules and the Electrical Properties of Membranes
• Intracellular Compartments and Protein Sorting
• Intracellular Membrane Traffic
• Energy Conversion: Mitochondria and Chloroplasts
• Cell Signaling
• The Cytoskeleton
• The Cell Cycle
• Cell Death

PART V: Cells in their Social Context

• Cell Junctions and the Extracellular Matrix
• Cancer
• Development of Multicellular Organisms
• Stem Cells and Tissue Renewal
• Pathogens and Infection
• The Innate and Adaptive Immune Systems

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