Free download Biochemistry: Concepts and Connections (2nd edition) written by Dean R. Appling, Spencer J. Anthony-Cahill and Christopher K. Mathews in pdf.
As genomics and informatics revolutionize biomedical science and health care, we must prepare students for the challenges of the twenty first century and ensure their ability to apply quantitative reasoning skills to the science most fundamental to medicine: biochemistry.
We have written Biochemistry: Concepts and Connections to provide students with a clear understanding of the chemical logic underlying the mechanisms, pathways, and processes in living cells. The title reinforces our vision for this book—twin emphases upon fundamental concepts at the expense of lengthy descriptive information, and upon connections, showing how biochemistry relates to all other life sciences and to practical applications in medicine, agricultural sciences, environmental sciences, and forensics.
Inspired by our experience as authors of the biochemistry majors’ text, Biochemistry, Fourth Edition and the first edition of this book, and as teachers of biochemistry majors’ and mixed-science-majors’ courses, we believe there are several requirements that a textbook for the mixed-majors’ course must address:
- The need for students to understand the structure and function of biological molecules before moving into metabolism and dynamic aspects of biochemistry.
- The need for students to understand that biochemical concepts derive from experimental evidence, meaning that the principles of biochemical techniques must be presented to the greatest extent possible.
- The need for students to encounter many and diverse real-world applications of biochemical concepts.
- The need for students to understand the quantitative basis for biochemical concepts. The Henderson–Hasselbalch equation, the quantitative expressions of thermodynamic laws, and the Michaelis–Menten equation, for example, are not equations to be memorized and forgotten when the course moves on. The basis for these and other quantitative statements must be understood and constantly repeated as biochemical concepts, such as mechanisms of enzyme action, are developed. They are essential to help students grasp the concepts.
Contents
- Biochemistry and the Language of Chemistry
- The Chemical Foundation of Life: Weak Interactions in an Aqueous Environment
- The Energetics of Life
- Nucleic Acids
- Introduction to Proteins: The Primary Level of Protein Structure
- The Three-Dimensional Structure of Proteins
- Protein Function and Evolution
- Enzymes: Biological Catalysts
- Carbohydrates: Sugars, Saccharides, Glycans
- Lipids, Membranes, and Cellular Transport
- Chemical Logic of Metabolism
- Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway
- The Citric Acid Cycle
- Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism
- Photosynthesis
- Lipid Metabolism
- Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates
- Amino Acid and Nitrogen Metabolism
- Nucleotide Metabolism
- Mechanisms of Signal Transduction
- Genes, Genomes, and Chromosomes
- DNA Replication
- DNA Repair, Recombination, and Rearrangement
- Transcription and Posttranscriptional Processing
- Information Decoding: Translation and Posttranslational Protein Processing
- Regulation of Gene Expression
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