Free download The Molecules of Life: Physical and Chemical Principles by John Kuriyan, Boyana Konforti and David Wemmer in pdf.
According to the writers, “This book is the result of a decade-long series of discussions among the three of us, in which we considered how biology students should best prepare themselves to take advantage of the growing depth of information concerning molecular mechanisms in biology.
The central theme of this book is that the ways in which proteins, DNA, and RNA work together in a cell are connected intimately to the structures of these biological macromolecules. These structures, in turn, depend on interactions between the atoms in these molecules, and on the interplay between energy and entropy, which results in the remarkable ability of biological systems to self-assemble and control their own replication.
This book is not intended to be a comprehensive reference, nor does it contain the most recent biological breakthroughs and discoveries. Our goal in this textbook is to integrate fundamental concepts in thermodynamics and kinetics with an introduction to biological mechanism at the level of molecular structure. We have done so by choosing biological examples to illustrate the basic physical and chemical principles that underlie how biological molecules function.
We have written this textbook with an undergraduate audience in mind, particularly those students who have chosen biology or the health sciences as their principal area of study. We assume that students have taken introductory courses in physics and chemistry and have been introduced to differential calculus at a basic level.
We anticipate that the book will also be useful for graduate students in biology who have not taken courses in physical chemistry, or who seek to learn more about structural biology. We also hope that the book will be useful for scientists wishing to refresh their knowledge of the elementary principles of biological structure, thermodynamics, and kinetics.”
Part I: Biological Molecules
- From Genes to RNA and Proteins
- Nucleic Acid Structure
- Glycans and Lipids
- Protein Structure
- Evolutionary Variation in Proteins
Part II: Energy and Entropy
- Energy and Intermolecular Forces
- Linking Energy and Entropy: The Boltzmann Distribution
Part III: Free Energy
- Free Energy
- Chemical Potential and the Drive to Equilibrium
- Voltages and Free Energy
Part IV: Molecular Interactions
- Molecular Recognition: The Thermodynamics of Binding
- Specificity of Macromolecular Recognition
Part V: Kinetics and Catalysis
- The Rates of Molecular Processes
- Principles of Enzyme Catalysis
- Diffusion and Transport
Part VI: Assembly and Activity
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