Free download Principles of Biochemistry (5th edition) authored by Laurence A. Moran, H. Robert Horton, K. Gray Scrimgeour, and Marc D. Perry in pdf.
According to the writers, “We built the book explicitly for the beginning student taking a first course in biochemistry with the aim of encouraging students to think critically and to appreciate scientific knowledge for its own sake.
Parts One and Two lay a solid foundation of chemical knowledge that will help students understand, rather than merely memorize, the dynamics of metabolic and genetic processes. These sections assume that students have taken prerequisite courses in general and organic chemistry and have acquired a rudimentary knowledge of the organic chemistry of carboxylic acids, amines, alcohols, and aldehydes. Even so, key functional groups and chemical properties of each type of biomolecule are carefully explained as their structures and functions are presented.
You’ll notice the following improvements in this fifth edition:
- Key Concept margin notes are provided throughout to highlight key concepts and principles that students must know.
- Interest Boxes have been updated and expanded, with 45% new to the fifth edition. We use interest boxes to explain some topics in more detail, to illustrate certain principles with specific examples, to stimulate students curiosity about science, to show applications of biochemistry, and to explain clinical relevance.We have also added a few interests boxes that warn students about misunderstanding and misapplications of biochemistry. Examples include Blood Plasma and Sea Water; Fossil Dating by Amino Acid Racemization; Embryonic and Fetal Hemoglobins; Clean Clothes; The Perfect Enzyme; Supermouse; The Evolution of a Complex Enzyme; An Egregious Error; Mendels Seed Color Mutant; Oxygen Pollution of Earth’s Atmosphere; Extra Virgin Olive Oil;Missing Vitamins; Pulling DNA; and much more.
- New Material has been added throughout, including an improved explanation of early evolution (the Web of Life), more emphasis on protein protein interactions, a new section on intrinsically disordered proteins, and a better description of the distinction between Gibbs free energy changes and reaction rates. We have removed the final chapter on Recombinant DNA Technology and integrated much of that material into earlier chapters. We have added descriptions of a number of new protein structures and integrated them into two major themes: structure-function and multienzyme complexes. The best example is the fatty acid synthase complex in Chapter 16.
Part One: Introduction
Part Two: Structure and Function
- Amino Acids and the Primary Structures of Proteins
- Proteins: Three-Dimensional Structure and Function
- Properties of Enzymes
- Mechanisms of Enzymes
- Coenzymes and Vitamins
- Lipids and Membranes
Part Three: Metabolism and Bioenergetics
- Introduction to Metabolism
- Gluconeogenesis, the Pentose Phosphate Pathway, and Glycogen Metabolism
- The Citric Acid Cycle
- Electron Transport and ATP Synthesis
- Lipid Metabolism
- Amino Acid Metabolism
- Nucleotide Metabolism
Part Four: Biological Information Flow
- Nucleic Acids
- DNA Replication, Repair, and Recombination
- Transcription and RNA Processing
- Protein Synthesis
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