Free download Fundamentals of Molecular Virology (2nd Edition) by Nicholas H. Acheson in pdf.
This book is written for students who are learning about viruses for the first time in a university course at the undergraduate or graduate level. As the title implies, it concentrates on the molecular mechanisms of virus replication, and on the interactions between viruses and the cells in which they replicate.
The book approaches learning about virology by presenting a set of chapters each of which covers a specific virus family, using one or two well-studied viruses as examples. These chapters are each designed to tell a story about the viruses being considered, and to portray the “personality” of those viruses, with the idea that this will help students to learn about and remember each virus group.
The emphasis of this textbook is on virus replication strategies; it is directed towards university students studying microbiology, cell and molecular biology, and the biomedical sciences. It does not go deeply into pathogenesis, epidemiology, or disease symptoms.
However, substantial information and stories about medical and historical aspects of virology are included, particularly in introductory sections of each chapter. Students who understand what diseases are caused by particular viruses, and the importance of these diseases in human history, may be motivated to learn more about those viruses.
This textbook is designed to be used in a modular fashion. No course would be expected to use all the chapters in the book, nor necessarily in same order in which they appear. The organization of the book gives wide latitude to course coordinators to make their own choices of which virus groups will be covered.
Chapters are designed to accompany a 50-minute lecture on the subject, or in some cases, two or three such lectures. It should be possible to read each chapter in 30–60 minutes, including examination of figures and tables. Lecturers might want to supplement material given in the text with experimental methods or results, which are not covered because of lack of space.
Contents
Section I: Introduction to Virology
- Introduction to Virology
- Virus Structure and Assembly
- Virus Classification: The World of Viruses
- Virus Entry
Section II: Viruses of Bacteria and Archaea
- Single-Stranded RNA Bacteriophages
- Microviruses
- Bacteriophage T7
- Bacteriophage Lambda
- Viruses of Archaea
Section III: Positive-Strand RNA Viruses of Eukaryotes
- Cucumber Mosaic Virus
- Picornaviruses
- Flaviviruses
- Togaviruses
- Coronaviruses
Section IV: Negative-Strand and Double-Stranded RNA Viruses of Eukaryotes
- Paramyxoviruses and Rhabdoviruses
- Filoviruses
- Bunyaviruses
- Influenza Viruses
- Reoviruses
Section V: Small DNA Viruses of Eukaryotes
- Parvoviruses
- Polyomaviruses
- Papillomaviruses
Section VI: Larger DNA Viruses of Eukaryotes
- Adenoviruses
- Herpesviruses
- Baculoviruses
- Poxviruses
- Viruses of Algae and Mimivirus
Section VII: Viruses that Use a Reverse Transcriptase
- Retroviruses
- Human Immunodeficiency Virus
- Hepadnaviruses
Section VIII: Viroids and Prions
- Viroids and Hepatitis Delta Virus
- Prions
Section IX: Host Defenses Against Virus Infection
- Intrinsic Cellular Defenses Against Virus Infection
- Innate and Adaptive Immune Responses to Virus Infection
Section X: Antiviral Agents and Virus Vectors
- Antiviral Vaccines
- Antiviral Chemotherapy
- Eukaryotic Virus Vectors
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