Fundamentals of Biochemistry: Life at the Molecular Level (5th Edition) By Donald Voet, Judith G. Voet and Charlotte W. Pratt

Free download Fundamentals of Biochemistry: Life at the Molecular Level (5th edition) written by Donald Voet, Judith G. Voet and Charlotte W. Pratt in pdf.

The fifth edition of Fundamentals of Biochemistry includes significant changes and updates to the contents. In recognition of the tremendous advances in biochemistry, we have added new information about prion diseases, trans fats, membrane transporters, signal transduction pathways, mitochondrial respiratory complexes, photosynthesis, nitrogen fixation, nucleotide synthesis, chromatin structure, and the machinery of DNA replication, transcription, and protein synthesis.

New experimental approaches for studying complex systems are introduced, including next generation DNA sequencing techniques, cryo-electron microscopy, metabolomics, genome editing with the CRISPR–Cas9 system, and the role of noncoding RNAs in gene regulation. Notes on a variety of human diseases and pharmacological effectors have been expanded to reflect recent research findings.

Contents

PART I: Introduction

• Introduction to the Chemistry of Life
• Water

PART II: Biomolecules

• Nucleotides, Nucleic Acids, and Genetic Information
• Amino Acids
• Proteins: Primary Structure
• Proteins: Three-Dimensional Structure
• Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies
• Carbohydrates
• Lipids and Biological Membranes
• Membrane Transport

PART III: Enzymes

• Enzymatic Catalysis
• Enzyme Kinetics, Inhibition, and Control
• Biochemical Signaling

PART IV: Metabolism

• Introduction to Metabolism
• Glucose Catabolism
• Glycogen Metabolism and Gluconeogenesis
• Citric Acid Cycle
• Electron Transport and Oxidative Phosphorylation
• Photosynthesis
• Lipid Metabolism
• Amino Acid Metabolism
• Mammalian Fuel Metabolism: Integration and Regulation

PART V: Gene Expression and Replication

• Nucleotide Metabolism
• Nucleic Acid Structure
• DNA Replication, Repair, and Recombination
• Transcription and RNA Processing
• Protein Synthesis
• Regulation of Gene Expression

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