Free download RNA: the Epicenter of Genetic Information – A New Understanding of Molecular Biology written by John Mattick and Paulo Amaral in pdf.
According to the writers, “RNA likely underpinned the emergence of life, yet it is arguably the least appreciated of all biological macromolecules. For most of the past century, RNA has been regarded principally as an intermediary between gene and protein. However, most of the human genome expresses RNAs that do not encode proteins, which begs the question: why?
The understanding of the functions of RNA and the answer to this question are bound up with the history of molecular biology. The term ‘molecular biology’ was coined by the mathematician Warren Weaver in 19381 and has become synonymous with the nature, transmission and manifestation of genetic information, and the structure of the molecules involved.
The field had its roots in the discovery of DNA in 1869 and the identification of proteins and their enzymatic activity in the late 19th century, key events that gave birth to “the science of the chemistry of life”. Since then, proteins and DNA have been the primary focus of studies of cellular and developmental processes and the conceptions of ‘genes’, ‘gene expression’ and ‘gene regulation’.”
Key Features
- Documents the confused early history of DNA, RNA and proteins – a transformative history of molecular biology like no other.
- Integrates the influences of biochemistry and genetics on the landscape of molecular biology.
- Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress.
- Highlights the major pioneers and contributors to molecular biology, with a focus on RNA and non-coding DNA.
- Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology.
- Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.
Contents
- Overview
- The Genetic Material?
- Halcyon Days
- Worlds Apart
- Strange Genomes, Strange Genetics
- The Age of Aquarius
- All That Junk
- The Expanding Repertoire of RNA
- Glimpses of a Modern RNA World
- Genome Sequences and Transposable Elements
- The Human Genome
- Small RNAs with Mighty Functions
- Large RNAs with Many Functions
- The Epigenome
- The Programming of Development
- RNA Rules
- Plasticity
- Beyond the Jungle of Dogmas
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- Concepts of Genetics (12th edition) written by William S. Klug, Michael R. Cummings, Charolette A. Spencer, Michael A. Palladino and Darrell J. Killian
- Genetic Analysis: An Integrated Approach (3rd edition) written by Mark F. Sanders and John L. Bowman
- Biochemistry: The Molecular Basis of Life (7th edition) written by Trudy McKee and James McKee
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