Free download The Handbook of Medicinal Chemistry: Principles and Practice (2nd edition) by Simon Ward & Andrew Davis in pdf.
The second edition of The Handbook of Medicinal Chemistry offers a thoroughly revised and updated guide, combining insights from leading experts to provide both a broad overview and a deep dive into the latest advancements in the field.
This edition serves as an invaluable resource for students and professionals in medicinal chemistry, drug discovery, and development, conveying foundational principles within the context of innovative modalities shaping modern drug research.
The book underscores chemistry’s expanding role in target validation and translational technologies, making it a vital reference for understanding the field’s evolving landscape.
Featuring contributions from a diverse array of global specialists, this edition leverages their extensive expertise in medicinal chemistry, project leadership, and drug development across industry, academia, and charitable organizations, offering unmatched perspectives for anyone navigating or advancing in the field.
Contents
- Physicochemical Properties
- Synthesis in Medicinal Chemistry
- Useful Computational Chemistry Tools for Medicinal Chemistry
- Structure-based Design for Medicinal Chemists
- Fragment-based Ligand Discovery (FBLD)
- Machine Learning in Drug Design
- Drug Metabolism
- ADME Optimization in Drug Discovery
- Molecular Biology for Medicinal Chemists
- Assays
- In Vitro Biology: Measuring Pharmacological Activity that Will Translate to Clinical Efficacy
- Animal Models: Practical Use and Considerations
- Bioinformatics for Medicinal Chemistry
- Translational Science
- Discovery Toxicology in Lead Optimization
- Toxicology and Drug Development
- Patents for Medicines
- Target Validation for Medicinal Chemists
- Lead Generation
- Lead Optimisation: What You Should Know!
- Pharmaceutical Properties – The Importance of Solid Form Selection
- The Medicinal Chemistry and Process Chemistry Interface
- Clinical Drug Development
- SMN2 Splicing Modification by Small Molecules – A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases
- The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate
- Medicinal Chemistry for Neglected Diseases – Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness
- New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery
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You may also like to download the following books for free:
- Basic Principles of Drug Discovery and Development (2nd Ed.) by Benjamin E. Blass
- Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry (12th Ed.) By John M. Beale and John H. Block
- An Introduction to Medicinal Chemistry (5th Edition) By Graham L. Patrick
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