Free download Cell Biology (3rd edition) authored by Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz and Graham T. Johnson in pdf.
According to authors, “For this edition, we revised the entire book, taking the reader to the frontiers of knowledge with exciting new information on every topic. We start with new insights about the evolution of eukaryotes, followed by macromolecules and research methods, including recent breakthroughs in light and electron microscopy.
We begin the main part of the book with a section on basic molecular biology before sections on membranes, organelles, membrane traffic, signaling, adhesion and extracellular matrix, and cytoskeleton and cellular motility. As in the first two editions, we conclude with a comprehensive section on the cell cycle, which integrates all of the other topics.
The book emphasizes molecular mechanisms because they reveal the general principles of cellular function. As a further demonstration of this generality, we use a wide range of experimental organisms and specialized cells and tissues of vertebrate animals to illustrate these general principles.
We also use medical “experiments of nature” to illustrate physiological functions throughout the book, since connections have now been made between most cellular systems and disease. The chapters on cellular functions integrate material on specialized cells and tissues.
Epithelia, for example, are covered under membrane physiology and junctions; excitable membranes of neurons and muscle under membrane physiology; connective tissues under the extracellular matrix; the immune system under connective tissue cells, apoptosis, and signal transduction; muscle under the cytoskeleton and cell motility; and stem cells and cancer under the cell cycle and signal transduction.”
Contents
Section I: Introduction to Cell Biology
- Introduction to Cells
- Evolution of Life on Earth
Section II: Chemical and Physical Background
- Molecules: Structures and Dynamics
- Biophysical Principles
- Macromolecular Assembly
- Research Strategies
Section III: Chromatin, Chromosomes, and the Cell Nucleus
- Chromosome Organization
- DNA Packaging in Chromatin and Chromosomes
- Nuclear Structure and Dynamics
Section IV: Central Dogma: From Gene to Protein
- Gene Expression
- Eukaryotic RNA Processing
- Protein Synthesis and Folding
Section V: Membrane Structure and Function
- Membrane Structure and Dynamics
- Membrane Pumps
- Membrane Carriers
- Membrane Channels
- Membrane Physiology
Section VI: Cellular Organelles and Membrane Trafficking
- Posttranslational Targeting of Proteins
- Mitochondria, Chloroplasts, Peroxisomes
- Endoplasmic Reticulum
- Secretory Membrane System and Golgi Apparatus
- Endocytosis and the Endosomal Membrane System
- Processing and Degradation of Cellular Components
Section VII: Signaling Mechanisms
- Plasma Membrane Receptors
- Protein Hardware for Signaling
- Second Messengers
- Integration of Signals
Section VIII: Cellular Adhesion and the Extracellular Matrix
- Cells of the Extracellular Matrix and Immune System
- Extracellular Matrix Molecules
- Cellular Adhesion
- Intercellular Junctions
- Connective Tissues
Section IX: Cytoskeleton and Cellular Motility
- Actin and Actin-Binding Proteins
- Microtubules and Centrosomes
- Intermediate Filaments
- Motor Proteins
- Intracellular Motility
- Cellular Motility
- Muscles
Section X: Cell Cycle
- Introduction to the Cell Cycle
- G1 Phase and Regulation of Cell Proliferation
- S Phase and DNA Replication
- G2 Phase, Responses to DNA Damage, and Control of Entry into Mitosis
- Mitosis and Cytokinesis
- Meiosis
- Programmed Cell Death
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