Free download Casarett & Doull’s Toxicology: The Basic Science of Poisons (9th edition) by Curtis D. Klaassen in pdf.
The ninth edition of Casarett and Doull’s Toxicology: The Basic Science of Poisons continues to serve primarily as a core text or supplementary resource for graduate-level courses in toxicology. Building on the legacy of the previous eight editions, this edition strives to preserve the qualities that have made it a trusted resource for courses in environmental health and related fields.
It provides comprehensive coverage of toxicology, emphasizing foundational principles, key concepts, and critical thought processes that underpin the discipline, with a particular focus on the mechanisms of toxicity.
Research toxicologists will also find this edition to be an invaluable reference, offering updated insights into both specialized and peripheral areas of interest.
This edition reflects recent advancements in the field of toxicology, incorporating cutting-edge knowledge and technologies. Expanded discussions cover key biological processes such as apoptosis, autophagy, cytokines, growth factors, oncogenes, and cell cycling. Topics like receptors, gene regulation, and protective and repair mechanisms are also emphasized, providing a deeper understanding of toxicity at the molecular level.
In addition, the book highlights developments in transcription factors, signaling pathways, and the use of advanced models such as transgenic, knock-out, and humanized mice. These models offer valuable insights into toxicological mechanisms and facilitate more precise research. The role of polymorphisms and their impact on individual responses to toxicants is also explored in detail.
The edition further includes the latest technological advancements such as microarray analysis, second-generation sequencing, genomics, and proteomics. Emerging fields like epigenetics, exposomics, and microbiota studies are addressed, alongside innovative approaches like adverse outcome pathways, high-content screening, computational toxicology, organ-on-a-chip systems, and other state-of-the-art methods for understanding and regulating chemical toxicity.
Significantly revised and updated, this edition introduces new perspectives with over one-third of its chapters authored by contributors who have not participated in prior editions. References include not only traditional journal articles and reviews but also relevant internet resources, ensuring accessibility to the most current information.
Contents
- Unit I: General Principles of Toxicology
- Unit II: Disposition of Toxicants
- Unit III: Non-Organ-Directed Toxicity
- Unit IV: Target Organ Toxicity
- Unit V: Toxic Agents
- Unit VI: Environmental Toxicology
- Unit VII: Applications of Toxicology
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