Free download Some Assembly Required: Decoding Four Billion Years of Life, from Ancient Fossils to DNA written by Neil Shubin in pdf.
According to the writer, “Experiments with DNA promised to answer questions that were formerly the sole purview of fossil hunters. Moreover, an understanding of DNA could get to the genetic mechanism that drove the changes I was seeking to explain among ancient rocks.
Like fossil species in our past, I was going to have to evolve or go extinct. If extinction for a scientist is irrelevance, then a deep dive into genetics, developmental biology, and the world of DNA would keep me part of the intellectual action. Ever since those first journal articles, I have run a kind of split-brain laboratory, spending summers in the field looking for fossils and working the rest of the year with embryos and DNA.
Both approaches can be deployed in the service of answering a single question: How do large changes in the history of life come about?
For the past two decades, technological advances have arrived at a dizzying pace. Genome sequencers are now so powerful that the Human Genome Project, which took over a decade and cost billions of dollars, could now be completed in an afternoon for under one thousand dollars.
And sequencing is only one example: computing power and imaging technologies allow us to peer inside embryos and even to see molecules at work in cells. DNA technology has become so powerful that animals as diverse as frogs and monkeys can now be readily cloned, and mice can be engineered with the genes of humans or flies inside.
The DNA of almost any animal can now be edited, giving us the power to remove and rewrite the genetic code that builds bodies of almost every species of animal and plant. We can ask, at the level of DNA, what combination of genes makes a frog different from a trout, a chimpanzee, or a human?”
Contents
- Five Words
- Embryonic Ideas
- Maestro in the Genome
- Beautiful Monsters
- Copycats
- Our Inner Battlefield
- Loaded Dice
- Mergers and Acquisitions
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